Multiple vaccines are now available to help curb the threat of COVID-19, caused by the SARS-CoV-2 virus. And what about those many numbers in the total population who contract the virus, recover with seemingly little damage if any to their vascular system? 14 June 2021. See: https://www.dailymail.co.uk/news/article-9366963/Coronavirus-Pfizers-Covid-vaccine-linked-blood-clots-AstraZenecas-UK.html. These efforts range from understanding the structure of the virus to mobilizing the bodys immune reaction. The mRNA vaccination process hijacks the cell to encode these proteins so were not talking a limited number taken up by the vaccine itself after which no more are produced by the body. The Pfizer and Moderna COVID-19 vaccines use mRNA technology to instruct a person's cells on how to create a piece of a spike protein. Jason McLellan, a structural biologist at the University of Texas at Austin who has been studying spike proteins in other coronaviruses for years and whose work was fundamental for the development of COVID-19 vaccines, said Bridles statements are not correct. Had to look down and seen it ! Cellular biology 101. Your comment is exactly the type of thing that fails the smell test. currently one of the worlds greatest challenges. That could explain why some people have strokes, and why some people have issues in other parts of the body. if and how long-term immunity can be established. Accessed 29 June 2021. If you remove the replicating capabilities of the virus, it still has a major damaging effect on the vascular cells, simply by virtue of its ability to bind to this ACE2 receptor, the S protein receptor, now famous thanks to COVID, Manor explains. Jonas Salk used them to create his polio vaccine in the 1950s, and they're the bases for vaccines against other diseases including rabies and hepatitis A. Your support will accelerate the pace of breakthroughs in understanding disease and pave the way to new drug therapies. Indeed, there are those who have looked at the vaccine clinical trial data and made the observation that the rate of COVID-19 cases among the control group was too small relative to the reduction of cases in the vaccinated group to extrapolate a high rate of effectiveness for vaccines. The underlying mechanism involves S protein downregulation of AMPK and upregulation of MDM2, causing ACE2 destabilization. Segments of the interview were widely spread in social media platforms in English and Spanish. . Canadian Covid Care Alliance. 5 Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA (C.R.S., G.S.S.). what is the half -life or the time scale the mRNA and the proteins will be floating around until mRNA is degraded and the spike proteins are met by the immune system? Continue with Recommended Cookies, Representative images of vascular endothelial control cells (left) and cells treated with the SARS-CoV-2 Spike protein (right) show that the spike protein causes increased mitochondrial fragmentation in vascular cells. Bridle omits this information in his 37-page document, instead saying that detection of the mRNA was downplayed., Now we know the spike protein gets into circulation. physicians at UC San Diego and the VA hospital, Kaech Human Antibodies Target Many Parts of Coronavirus Spike Protein Wrapp, Daniel, et al. Salk Institute Verified account @salkinstitute. Why cant people sue pharmaceutical companies if they have disabling reactions or their family members die from it? The study, in which researchers administered a pseudovirus to hamsters, found the spike protein alone can damage vascular endothelial cells. But as the authors mention, the use of a pseudovirus is a limitation and findings need to be confirmed with the SARS-CoV-2 virus in the future. According to the Centers for Disease Control and Prevention, the most intensive safety monitoring in U.S. history has found that most of the reported side effects after COVID-19 vaccination are minor, such as pain at the injection site or fever. This is the issue, why create spikes inside cellular machinery? This binding disrupted ACE2s molecular signaling to mitochondria (organelles that generate energy for cells), causing the mitochondria to become damaged and fragmented. . Updated 9 June 2021. extended to treat other RNA viruses in the future. While the findings themselves arent entirely a surprise, the paper provides clear confirmation and a detailed explanation of the mechanism through which the protein damages vascular cells for the first time. Exposure to this pseudovirus resulted in damage to the lungs and arteries of an animal modelproving that the spike protein alone was enough to cause disease. Member of the faculty at Harvard Medical School and of Harvards Wyss Institute for Biologically Inspired Engineering. The research was supported by the National Institutes of Health, the National Natural Science Foundation of China, the Shaanxi Natural Science Fund, the National Key Research and Development Program, the First Affiliated Hospital of Xian Jiaotong University; and Xian Jiaotong University. . CDC.gov. There is no risk at all because all the vaccines that are being used presently, none of them have the live virus in it. If a burgler, theoretically, is born inside your house and cannot get out alive and is killed by the residents, there is no damage and no damage in the future at other houses. All Rights Reserved. Vaccine protects COVID-19 survivors against variants; virus' spike We show here that S protein alone can damage vascular endothelial cells (ECs) in vitro and in vivo, manifested by impaired mitochondrial function, decreased ACE2 expression and eNOS activity, and increased glycolysis. This binding disrupted ACE2s molecular signaling to mitochondria (organelles that generate energy for cells), causing the mitochondria to become damaged and fragmented. 31 Mar 2021. But researchers and health officials told FactCheck.org there is no mistake and that there is no evidence to support Bridles claims. Manor labs and Ogata's study confirm. The paper, published on April 30, 2021, in Circulation Research, also shows conclusively that COVID-19 is a vascular disease, demonstrating exactly how the SARS-CoV-2 virus damages and attacks the vascular system on a cellular level. This is not the first paper to show this, Magro (2020) showed this definitively.A synethetic mRNA gene is a great way to make spike proteins and cause damage because lipid nano-particles can travel into the brain whereas the virus does not. 10 June 2021. Save my name, email, and website in this browser for the next time I comment. Covid makes most people not ill at all or a little ill as well.No one knows that. Yes, it's true that the spike protein with the N-protein, will not replicate. If its comforting, a little back-of-the-envelope math shows that people are at least 50,000 times more likely to die from covid than to get a serious complication from the vaccine. Unless the MRNA vaccine gets into one of your cells exactly while its splitting, past the cell wall, past the cell nucleus, guide its self into the exact spot it can attach its self to your cells own RNA (when dividing) its not going to cause any harm to your body. For instance, behold Alex Berenson, the " pandemic's wrongest man ", crowing about the study: As smoking guns go, this study is high-caliber. The Salk Institute's study concluded that Covid-19 vaccines are an effective and safe way to protect people from the virus. Rajasree Kalagiri Bound to phosphohistidine. The research was supported by the National Institutes of Health, the National Natural Science Foundation of China, the Shaanxi Natural Science Fund, the National Key Research and Development Program, the First Affiliated Hospital of Xian Jiaotong University; and Xian Jiaotong University. Of course, none of this even begins to account for how vaccines will alter our immune response, for better or for worse, to COVID-19 variants. SARS-CoV-2 spike protein induces abnormal inflammatory blood clots Other authors on the study are Yuyang Lei and Zu-Yi Yuan of Jiaotong University in Xian, China; Cara R. Schiavon, Leonardo Andrade, and Gerald S. Shadel of Salk; Ming He, Hui Shen, Yichi Zhang, Yoshitake Cho, Mark Hepokoski, Jason X.-J. The novel coronavirus spike protein plays additional key role in illness. Only small fragments of the ubiquoitim proteosome protein degradation process of the induced spike protein are presented on the surface of the cell by the MHC 1 ANTIGEN presentation system. The body then recognises these as foreign and starts to make antibodies. Before it is destroyed it causes micro clots if the spike producing cell is part of the endothelial cell wall. For more, see How safe are the vaccines?. Vol. I agree that if the mRNA vaccines themselves stimulate the human bodys cells to produce spike proteins, shouldnt there be some concern that by this process the mRNA vaccines could ultimately cause the same vascular damage? . PDF New COVID-19 booster vaccine offers high level of protection in mice With mRNA vaccine technology the spike protein is made inside the cellular machinery, but it goes on to be destroyed once it is made inside the cells and CAN NOT EXIT the Cell intact. Retweeted. FauXi's Great Leap Backwards | The Spectator Australia We and our partners use cookies to Store and/or access information on a device. Some such claims are. According to a statement sent to FactCheck.org by NIAID, if enough excess spike proteins are shed into the bloodstream and bind to human cells expressing the ACE2 receptor, an infected person could theoretically experience additional symptoms. Be it cancer or Alzheimers, aging or diabetes, Salk is where In addition, the Food and Drug Administration inspects vaccine production facilities and reviews manufacturing protocols to make sure vaccine doses are of high-quality and free of contaminants. Did anyone of you develop those vaccines? Looking into the adverse event database in the United States, we have found evidence of suckling infants experiencing bleeding disorders in the gastrointestinal tract.. treatments using nanoparticles. The Spike (S) protein of the SARS-CoV-2 virus is critical for its ability to attach and fuse into the host cells, leading to infection, and transmission. will target i) SARS-CoV-2 prevention by creating synthetic 27 apr 2021. However, vaccine-generated spike proteins cant do that fusion because they are locked in the pre-fusion shape. In contrast, the virus is able to produce many copies of itself in a very short time before the body can make any attempt to control it. Which process(es) dominate will depend on each individuals particular immune system. mRNA created Spike proteins CAN NOT free float around and infect other AC2 receptors in your body. 21 . generating protective immunity. Fact Check-COVID-19 vaccines are not 'cytotoxic' | Reuters As mentioned, the spike protein is itself a pathogen. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827936/#:~:text=SARS%2DCoV%2D2%20uses%20its%20viral%20membrane%20fusion%20protein%2C,(ARDS)%20%5B5%5D. How can you give the odds of someone dying of covid vs a vaccine like AstraZenica when you dont even know their medical history or current medications? IANS. while a professor at the Salk Institute, Holley shared the Nobel Prize for his work on how these . COVID-19 Vaccines While Pregnant or Breastfeeding. And look into the heavens and see the sun and all the stars in Heaven. A lot of people think of it as a respiratory disease, but its really a vascular disease, says Assistant Research Professor Uri Manor, who is co-senior author of the study. The, unpublished study found antibodies in the breast milk from all of the workers andminimal amounts of vaccine mRNA., document, instead saying that detection of the mRNA was downplayed., is designed to detect potential problems thats why its there but it does not show whether the vaccines. Most use a recombinant spike glycoprotein: either mRNA based (the Moderna and Pfizer-BioNTech vaccines), via an adenovirus vector (the Oxford-AstraZeneca, CanSino, and Johnson & Johnson vaccines), or via injection of the protein itself (the Novavax vaccine). overreaction seen in some COVID-19 patients. The mRNA lipid coated vesicles (numbering in the trillions from the jab also enter the blood stream where they travel the whole body even past the blood brain barrier. It also means that while naturally acquired immunity from the infection of SARS COv 2 will have targets from all different parts of the virus, the antibodies produced by the vaccine will only be active for small fragments of the transfigured spike protein induced by the vaccine mRNA. One key vaccine safety surveillance program is the Vaccine Adverse Event Reporting System, or VAERS, which is an early warning system run by the Centers for Disease Control and Prevention and FDA. Aging is a complex puzzle, but by applying a collaborative, multidisciplinary approach, Salk scientists are putting its many pieces together. There are no AC2 receptors inside the cell. The cells . Those particles slowly replicate and start sending signals to your bodys immune system, so it manages to prepare and respond to the infection before it takes you down or even disappear unnoticed.My other assumption is about the new virus variants: the ones that draw attention do not come from the second most populated country with very high population density India, as it should be in theory. Bryam Bridle profile. Antisevere acute respiratory syndrome coronavirus 2 antibodies induced in breast milk after Pfizer-BioNTech/BNT162b2 vaccination. American Journal of Obstetrics & Gynecology. This has been shown to happen by researchers or doctors perfforming a D Dimr test on recently vaccinated people.